1431 over-50s with mild prostate complaints were divided into 3 groups.

One group took a placebo daily, another group took a pumpkin extract supplement every other day and another group ate 10 grams of pumpkin seed every day.

The men who ate pumpkin seeds showed a greater decrease in complaints than in the placebo, or the supplement group.

“treatment with pumpkin seed results in a substantial improvement in lower urinary tract symptoms/benign prostatic hyperplasia.”

https://www.karger.com/Article/FullText/362903

“Atherogenic rats supplemented with pumpkin seeds showed a significant decrease in their concentrations of total cholesterol and LDL”

“Concentrations of HDL-C were also significantly elevated”

“The current study showed that pumpkin seeds have a beneficial effect on atherogenic rats as it caused a significant reduction in serum concentrations of TC(total cholesterol) and LDL-C and increased the serum levels of HDL-C.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746528/

Rats were given pumpkin seed extract every day for 28 days. Certain groups of rats were made diabetic. The rats given pumpkin seed extract showed significant improvements in blood glucose levels. 

“In case of severely diabetic rats a significant reduction of 39.33% was observed in FBG(fasting blood glucose) levels”

“The effectiveness of the extract in severely diabetic rats was almost at par as compared with the synthetic drug, glipizide during FBG studies.”

“The plausible mechanism by which pumkin seed extract decreases blood sugar levels may be by increasing the pancreatic secretion of insulin”

https://www.sciencedirect.com/science/article/pii/S2225411016303017?via%3Dihub

Subjects were given a placebo meal, or a meal with 65 grams of pumpkin seeds. The pumpkin seed group had a better blood sugar response.

“Consumption of 65 g of pumpkin seed markedly reduced postprandial glycemia”

“Glucose iAUC was significantly lower in the pumpkin seed group compared with control group (reduction of ~35%)”

https://www.sciencedirect.com/science/article/abs/pii/S0271531717300805?via%3Dihub