The pistachio is a seed, and a culinary nut rather than a botanical one. It grows inside a fruit with a hard shell, on a tree in the cashew family. That family also holds the mango and poison ivy. When the fruit ripens, the shell splits partly open with a pop, a trait people have selected for.
Raw pistachios have 560 calories per 100 g, or 159 in an ounce (28 g), and 20.2 g of protein per 100 g. The protein is complete, scoring 100 out of 100 for essential amino acids. An ounce also gives 3 g of fiber and 28% of the Daily Value for vitamin B6.
Compared with other nuts, pistachios are high in lutein, the pigment of the retina. An ounce has 823 µg (micrograms) of lutein and zeaxanthin.
Pistachios may also hold slightly less usable energy than their label suggests. In a feeding study, the measured energy was 5% below the standard calculation. And the shell may help with portions. In two small university studies, people who ate in-shell pistachios, or who left the empty shells in sight, ate fewer calories.
Health benefits of pistachios
The top findings from 29 studies, strongest evidence first
What the stars mean
- Strong. Several randomized trials, pooled in a meta-analysis, point the same way, or regulators (FDA or EFSA) have approved the claim.
- Moderate. Good randomized trials support it, but there are fewer of them, or their results vary.
- Limited. Small, short or single trials, or mixed results. Promising, but it needs confirmation.
Population and lab studies get no stars: they show a link or a mechanism, not proof.
How we rate evidence →- ★★★Lower “bad” LDL cholesterolAcross 12 trials of pistachios alone, LDL fell by 3.8 mg/dL. Across 61 trials of tree nuts as a group, one daily ounce lowered it by 4.8 mg/dL.
- ★★Slightly lower blood sugar markers in prediabetesAbout 57 g of pistachios a day lowered fasting blood sugar and insulin resistance in 54 adults with prediabetes. In another trial, HbA1c (average blood sugar) fell 0.2 points, though pooled trials found no HbA1c change.
- ★★Slightly lower blood pressureThe top number fell by about 3 points (2.9 mm Hg systolic) across 17 trials. A pooled analysis of 13 trials found a drop of 2.1 mm Hg systolic, and no change in the bottom number.
- ★★No clear effect on weightAcross 11 trials, body weight and waist size did not change in a clear way. In a 4-month weight-loss program, people lost 4.9% of their weight with pistachios and 5.1% without.
- ★Fewer calories eaten from in-shell nutsIn 140 students, people ate about 125 calories of in-shell pistachios against 211 of shelled ones. In another study, shells left in sight cut daily intake by 48 calories (216 against 264).
All 29 studies, strongest evidence first
Tree nuts, pistachios included, lowered LDL cholesterol by 4.8 mg/dL
This meta-analysis covered 61 controlled trials of tree nuts, including pistachios, walnuts and almonds, in 2,582 people. Trials lasted 3 to 26 weeks, and the LDL drop is for one daily serving (1 oz, 28 g). Total cholesterol fell 4.7 mg/dL (milligrams per deciliter of blood), and the effect was stronger at 60 g or more a day. It did not differ by nut type, so this shows what nuts do as a group, not pistachios alone.
Pistachios cut LDL 3.8 mg/dL and triglycerides 11.2 mg/dL
This meta-analysis pooled 12 randomized trials (where chance decides who eats pistachios) of pistachios alone in adults. Total cholesterol fell 7.5 mg/dL, while HDL (“good”) cholesterol did not change significantly. The authors say larger trials are needed to confirm the results.
Pistachios lowered fasting blood sugar and insulin resistance in prediabetes
In this crossover trial, 54 Spanish adults with prediabetes tried both diets in turn, for 4 months each. The pistachio diet had 57 g a day; the nut-free control diet matched it for calories, protein, fiber and saturated fat. Fasting insulin, fibrinogen and oxidized LDL also fell, and the gut hormone GLP-1 rose.
Pre-meal pistachios lowered HbA1c 0.2 points in prediabetes
In this randomized trial, 120 Asian Indian adults with prediabetes (109 finished) ate 30 g of pistachios before breakfast and before dinner for 12 weeks. HbA1c, a long-term blood sugar measure, fell against a usual diet without nuts, but fasting and 2-hour glucose did not change significantly. Triglycerides and waist size fell, and on a glucose monitor the blood sugar rise was 28% smaller after breakfast and 17% after dinner. The authors report no conflict of interest.
Pistachios lowered fasting blood sugar and insulin resistance, not HbA1c
This meta-analysis pooled 6 randomized trials in people with diabetes, prediabetes or metabolic syndrome. Fasting insulin did not change significantly either. Only six trials could be pooled, and the authors note that earlier results were mixed.
Pistachios lowered systolic pressure 2.9 mmHg and fasting glucose 3.6 mg/dL
This meta-analysis pooled 17 randomized trials in 940 adults; systolic pressure is the top blood pressure number. HDL cholesterol rose by 1.4 mg/dL. Diastolic pressure (the bottom number), waist size and BMI (body mass index) did not change.
Pistachios lowered systolic pressure 2.1 mmHg, not diastolic or inflammation
This meta-analysis pooled 13 randomized trials in 563 people. Inflammation markers such as C-reactive protein and TNF-alpha did not change significantly. Neither did artery widening after a pressure test (flow-mediated dilation), body weight, BMI or waist size, and the authors call for larger trials.
Pistachio diets lowered BMI by 0.18 points, not weight or waist
This meta-analysis pooled 11 randomized trials in 1,593 people. Body weight was 0.22 kg lower and waist size 0.76 cm larger on pistachios. Neither difference was significant, so both could be chance.
Pistachios in a weight-loss program did not change weight loss
This randomized trial put 100 overweight or obese adults on a 4-month weight-loss program. One group added 1.5 oz (42 g) of pistachios a day. They lost 4.9% of their weight, against 5.1% without pistachios, and both groups cut BMI and waist size. Only the pistachio group had lower blood pressure and higher blood lutein and carotenes; the American Pistachio Growers funded the trial.
Two servings of pistachios a day lowered LDL cholesterol by 11.6%
In this controlled-feeding crossover trial, 28 adults with raised LDL ate each diet for 4 weeks. The diets had no pistachios, 1 serving or 2 servings a day, the highest at 20% of calories. Total cholesterol fell 8% on 2 servings. The ratio of LDL to HDL fell 3% on 1 serving and 11% on 2.
Pistachios raised macular pigment in the eye in low-lutein adults
This single-blind trial gave 36 middle-aged and older adults 2 ounces of pistachios a day for 12 weeks. They had low lutein intake and low starting macular pigment, the yellow pigment at the center of the retina. Against their usual diet, pigment rose within 6 weeks at all four spots measured and stayed up at 12 weeks, and blood lutein followed. Whether this protects vision was not tested, and the American Pistachio Growers funded the trial.
In-shell pistachios cut calories eaten by 41% against shelled ones
In this study, 140 university students picked a portion and ate it at leisure during a class. They ate about 125 calories with in-shell nuts against 211 with shelled nuts, and fullness and satisfaction did not differ. The authors suggest the extra time to shell the nuts, or the extra volume, may explain it. It was a convenience sample (whoever was available), not a clinical trial.
Visible shells cut daily intake by 48 calories, 216 against 264
This study offered 118 faculty and staff in-shell pistachios at their desks for 8 hours on two days. On one day the shells stayed in a bowl, and on the other they were cleared every 2 hours. Fullness and satisfaction did not differ. It was a small convenience sample.
Pistachios lowered triglycerides from 1.84 to 1.56 mmol/L in diabetes
In this crossover feeding trial, 30 adults with well-controlled type 2 diabetes got 20% of calories from pistachios for 4 weeks. Total cholesterol also fell (4.15 to 4.00 mmol/L, millimoles per liter), and fructosamine, a longer-term blood sugar marker, was lower. Fasting glucose, insulin, inflammation markers and artery function did not change. The American Pistachio Growers supported the trial.
Pistachios lowered 24-hour systolic pressure 3.5 mmHg in type 2 diabetes
In this crossover feeding trial, 30 adults with well-controlled type 2 diabetes got 20% of energy from pistachios for 4 weeks. Blood pressure at rest and under mental stress did not differ between diets. The 24-hour result came from 21 people and was borderline. The American Pistachio Growers supported the trial.
Pistachios lowered HbA1c by 0.4 points in type 2 diabetes
In this crossover trial, 48 people with type 2 diabetes ate 25 g of pistachios twice a day for 12 weeks. They also had a control meal without nuts, with an 8-week break (washout) between phases. Over both phases, fasting blood glucose fell 16 mg/dL more than on the control meal. BMI, blood pressure, insulin resistance and CRP (an inflammation marker) did not change significantly.
In-shell pistachios daily lowered LDL from 137 to 128 mg/dL
In this open-label trial, 60 adults with mildly abnormal blood fats were randomly given lifestyle advice alone or with pistachios for 3 months. Everyone knew their group, and the pistachio group ate 80 g in the shell a day, about 40 g shelled. HDL cholesterol rose and one measure of artery stiffness fell. Most other artery measures were not significantly different from the control group.
Two daily servings of pistachios raised blood lutein and lowered oxidized LDL
In this crossover feeding trial, 28 adults with raised LDL ate each diet for 4 weeks. Blood gamma-tocopherol, a form of vitamin E, was also higher on 2 servings. The drop in oxidized LDL tracked the fall in LDL cholesterol itself. After accounting for that, the links with lutein and vitamin E were modest and not significant.
Pistachios supply about 5% less usable energy than standard calorie math predicts
In this crossover feeding study, 16 volunteers ate 0, 42 or 84 g of pistachios a day for 3 weeks. Energy in their food and waste was measured. Measured energy was 22.6 kJ/g against 23.7 kJ/g from standard factors (kJ, kilojoules, is a unit of energy). LDL cholesterol was 6% lower on the pistachio diets.
A daily pistachio snack did not change evening eating, fullness or weight
This pilot trial gave 60 healthy French women a 56 g pistachio snack a day for 4 weeks. The comparison was savory biscuits with the same calories and protein. Thiamin, vitamin B6, copper and potassium intakes were higher in the pistachio group. The American Pistachio Growers funded the study, and several authors consult for the group.
15 people, moderately high cholesterol: no drop in total or LDL cholesterol
In this randomized crossover trial, people with moderately high cholesterol got 15% of calories from pistachios for 4 weeks. HDL cholesterol rose by 2.3 mg/dL, and the ratios of total and LDL to HDL cholesterol improved. Fiber intake was 15 g higher. Triglycerides, BMI and blood pressure did not change.
Pistachios changed no blood fat or sugar marker in healthy young men
In this crossover trial, 27 young men with normal blood fats and glucose ate 1.5 or 3 oz of pistachios a day for two weeks. After a hard downhill run, LDL cholesterol fell by about 8 to 9 mg/dL, but only in the high-dose period. The American Pistachio Growers funded the trial.
Eating pistachios increased butyrate-producing gut bacteria
In this crossover feeding study, 16 volunteers ate 0, 1.5 or 3 servings a day for 18 days, and gene sequencing read their stool bacteria. Pistachios changed the gut bacteria more than almonds did in a parallel study of 18 people, and lactic acid bacteria fell. Bifidobacteria did not change. Butyrate is a fatty acid that gut bacteria make.
Pistachios raised erectile function scores from 36 to 54 in 17 men
The men, all with erectile dysfunction, ate 100 g of pistachios a day for 3 weeks. This small study had no comparison group, so it cannot separate pistachios from expectation. Blood flow on ultrasound (peak systolic velocity) also rose, and total and LDL cholesterol fell.
28 g more nuts daily linked to 0.78 times the death risk
This meta-analysis pooled 20 prospective studies (29 publications) of all nuts combined, counting deaths from any cause. Tree nuts and peanuts gave similar results. Coronary heart disease risk was lower (relative risk 0.71), and so was total cancer (0.85). People who eat nuts differ in other ways, so these cohort studies cannot prove cause, and none is about pistachios alone.
More nuts linked to lower cardiovascular disease (0.85) and death (0.77)
This meta-analysis pooled 19 prospective cohort studies, which follow groups of people over time. It compared the highest with the lowest nut intake, as relative risks; the death figure is for deaths from cardiovascular disease. There was no link with stroke or heart failure. The certainty of the evidence was rated from moderate to very low, and it covers nuts as a group.
Lab digestion model: almost 100% of lutein and vitamin E forms released
A dynamic lab model of the human stomach digested raw pistachios, roasted salted pistachios and muffins made with raw pistachios. More than 90% of the polyphenols (plant compounds) were released in the stomach step, and raw and roasted salted nuts did not differ. A muffin matrix lowered release of two polyphenols (protocatechuic acid 78%, luteolin 36%). No people were involved: it shows the lutein is available, not that it reaches the eye.
In mice, pistachios lowered blood cholesterol, liver fat and body fat mass
Mice on a high-fat diet got pistachios either from the start (prevention) or added later (reversal). Body weight, food intake and blood sugar did not change. The rise in triglycerides was prevented but not reversed.
In fat-fed mice, pistachios lowered blood TNF-alpha and IL-1 beta
Three groups of 8 mice ate a standard diet, a high-fat diet or a high-fat diet with pistachios (180 g/kg) for 16 weeks. These blood markers signal inflammation. Pistachios also changed the gut bacteria, and fat tissue and liver inflammation were lower. A measure of gut barrier function improved.
Who should be careful with pistachios
Most people can eat pistachios freely. Take a little care if one of these applies:
- Tree nut allergy. Pistachio is a tree nut, and tree nuts are one of the major allergens that US labels must declare. It is closely linked to cashew allergy. In an Israeli group of 100 children with cashew allergy, 82 were also allergic to pistachio. Avoid it unless your allergist says otherwise.
- Salted pistachios. Raw pistachios have about 1 mg of sodium per 100 g. Dry roasted salted ones have 428 mg per 100 g in USDA data, about 120 mg in an ounce (28 g). That is roughly 5% of the 2,300 mg Daily Value, so choose unsalted if you limit sodium.
- Aflatoxin. Pistachios are among the foods most prone to the molds that make aflatoxins. These toxins are linked to liver cancer at high exposure. The EU allows 8 µg/kg of aflatoxin B1 and 10 µg/kg in total in pistachios sold to consumers. The FDA treats pistachios above 20 ppb (parts per billion) as adulterated. The EU also runs extra import checks on pistachios from some origins. Lots sold in regular stores must meet these limits, so the risk for most people is small.
How to choose, store and eat pistachios
- In the shell: in one study, people given in-shell pistachios ate 41% fewer calories than people given shelled ones. In another, leaving the empty shells in sight cut intake by 48 calories. Both studies were small.
- Raw or roasted: in a digestion model, raw and roasted salted pistachios released their polyphenols, lutein and vitamin E alike. Unsalted keeps sodium near 1 mg per 100 g.
- How much: the FDA claim and one weight-loss trial used 1.5 ounces (42 g) a day. The prediabetes trial used 57 g and the eye pigment trial 2 ounces. An ounce is 159 calories.
Keep pistachios in a clean, moisture-free, airtight container. In the refrigerator at 40°F (4°C) or lower, they keep for up to a year. In the freezer at 0°F (−18°C) or lower, they keep for three years, according to University of California extension.
Sources
- Food allergies. FDA.
- Goldberg MR, Appel MY, Tobi K, et al. Validation of the NUT CRACKER diagnostic algorithm and prediction for cashew and pistachio co-allergy. J Allergy Clin Immunol Pract. 2024.
- Costa J, Silva I, Vicente AA, Oliveira MBPP, Mafra I. Pistachio nut allergy: an updated overview. Crit Rev Food Sci Nutr. 2019.
- Nuts, pistachio nuts, dry roasted, with salt added (FDC 169426). USDA FoodData Central.
- Compliance Policy Guide Sec. 570.500: aflatoxins in pistachio nuts. FDA. 2021.
- Commission Regulation (EU) 2023/915 on maximum levels for certain contaminants in food, Annex I, entries 1.1.8 and 1.1.9. European Commission. 2023.
- New EU maximum levels for contaminants in foods: aflatoxins, metals, and more. Food Safety Magazine.
- EU updates import controls for food of non-animal origin. Food Safety News. 2024.
- Qualified health claim: nuts and coronary heart disease. FDA letter of enforcement discretion. 2003.
- Honselman CS, Painter JE, Kennedy-Hagan KJ, et al. In-shell pistachio nuts reduce caloric intake compared to shelled nuts. Appetite. 2011.
- Kennedy-Hagan K, Painter JE, Honselman C, et al. The effect of pistachio shells as a visual cue in reducing caloric consumption. Appetite. 2011.
- Mandalari G, Bisignano C, Filocamo A, et al. Bioaccessibility of pistachio polyphenols, xanthophylls, and tocopherols during simulated human digestion. Nutrition. 2013.
- Mosbacher S. Storing and preserving fresh nuts. University of California Agriculture and Natural Resources. 2020.
History of pistachios
The word pistachio comes from an ancient Persian word, pistag. The tree is native to southern Central Asia, including northern Afghanistan and northeastern Iran. The earliest evidence of production comes from Bronze Age Central Asia, at Djarkutan in what is now Uzbekistan.
Pistachio was probably domesticated within that range about 3,000 years ago. A 2022 study argues it spread west by at least 2,000 years ago, and east only at the end of the first millennium AD. Its seeds stayed rare at archaeological sites outside its home range even into the mid-second millennium AD.
Greek writers such as Theophrastus and Dioscorides described the tree, and the Romans brought it from Asia to Europe in the first century AD. It reached California as a garden tree in 1854. The USDA’s David Fairchild brought in hardier types from China in 1904 and 1905.
The crop was promoted commercially from 1929, and the first commercial harvest in California came in 1976.
Today the United States, Turkey and Iran produce about 87% of the world crop. In 2024 world production was about 1.38 million tonnes. The United States grew about 499,000 tonnes, Turkey 383,000 and Iran 316,000.
Pistachio shells are naturally beige. They were once dyed red to hide stains left by hand picking, but most nuts are now harvested by machine and left undyed. Large piles of moist pistachios can heat themselves because of their oil. They can catch fire if stored with combustible fabric such as jute.
Sources
- Nezami E, Gallego PP. History, phylogeny, biodiversity, and new computer-based tools for efficient micropropagation and conservation of pistachio (Pistacia spp.) germplasm. Plants (Basel). 2023.
- Mir-Makhamad B, Bjørn R, Stark S, Spengler R. Pistachio (Pistacia vera L.) domestication and dispersal out of Central Asia. Agronomy. 2022.
- Pistachio. Wikipedia.
Frequently asked questions about pistachios
Are pistachios good for you?
For most people, yes: an ounce (28 g) of raw pistachios has 159 calories, 5.7 g of protein and 3 g of fiber. It also gives 28% of the Daily Value for vitamin B6. In a meta-analysis of 12 trials, pistachios lowered LDL cholesterol by 3.8 mg/dL; in 13 trials, they lowered systolic blood pressure by 2.1 mmHg. These are small effects with moderate evidence, and growers’ groups paid for many of the trials.
How many pistachios should you eat a day?
No study here sets an ideal amount, but the trials give a range. The FDA’s qualified heart claim uses 1.5 ounces (42 g) a day of most nuts. Trials used 57 g a day in prediabetes and 2 ounces a day for eye pigment. An ounce is 159 calories, so 1.5 ounces is about 240.
Do pistachios lower cholesterol?
Slightly. A meta-analysis of 12 trials found LDL cholesterol 3.8 mg/dL lower and triglycerides 11.2 mg/dL lower, with no clear change in HDL. In a feeding trial, 2 servings a day lowered LDL by 11.6%. But a trial in 15 people with moderately high cholesterol found no significant change in total or LDL cholesterol.
Are pistachios good for weight loss?
No trial shows that they cause weight loss. In 100 overweight adults on a weight-loss program, adding 1.5 ounces a day made no difference. They lost 4.9% of their weight, against 5.1% without pistachios. Pistachios have 560 calories per 100 g, so portions matter; eating them in the shell cut calories by 41% in one small study.
Are pistachios good for people with diabetes?
They can fit, and the evidence is moderate. In 54 adults with prediabetes, 57 g a day for 4 months lowered fasting blood sugar and insulin resistance.
A meta-analysis of 6 trials found the same for fasting glucose but not for HbA1c. In 120 Asian Indian adults with prediabetes, HbA1c fell by 0.2 points. Check portions and choices with your care team.
Are pistachios high in protein?
Fairly. Raw pistachios have 20.2 g of protein per 100 g, or 5.7 g in an ounce (28 g), about 14% of their calories. The protein is complete, scoring 100 out of 100 for essential amino acids.
Are pistachios good for your eyes?
Possibly, but the evidence is early. An ounce has 823 µg of lutein and zeaxanthin, the pigments of the retina. In a 36-person trial, 2 ounces a day for 12 weeks raised macular pigment in adults with low lutein intake. Whether that protects against eye disease was not tested, and the American Pistachio Growers funded the trial.
Are salted pistachios bad for you?
Salt is the main difference. Raw pistachios have about 1 mg of sodium per 100 g. USDA lists 428 mg per 100 g for dry roasted salted ones, about 120 mg in an ounce. That is roughly 5% of the Daily Value: modest for one ounce, but it adds up over several handfuls or if you limit sodium.
